PH SENSITIVE PEPTIDE FUNCTIONALIZED NANOPARTICLES FOR CO-DELIVERY OF ERLOTINIB AND DAPT TO RESTRICT THE PROGRESS OF TRIPLE NEGATIVE BREAST CANCER

pH sensitive peptide functionalized nanoparticles for co-delivery of erlotinib and DAPT to restrict the progress of triple negative breast cancer

Although a variety of Caravan drug delivery strategies have been designed for enhancing the treatment of Triple negative breast cancer (TNBC), combating with TNBCs is still dramatically challenged by the selection of appropriate therapeutic targets and insufficient tumor accumulation or inner penetration of chemotherapeutics.To address these issues

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Extracellular Pgk1 enhances neurite outgrowth of motoneurons through Nogo66/NgR-independent targeting of NogoA

NogoA inhibits neurite outgrowth of motoneurons (NOM) through interaction with its receptors, Nogo66/NgR.Inhibition of Nogo receptors rescues NOM, but not to the extent exhibited by NogoA-knockout mice, suggesting Ringette Stick the presence of other pathways.We found that NogoA-overexpressing muscle cells reduced phosphoglycerate kinase 1 (Pgk1) s

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Control method for seamless switching in hydrogen energy and pantograph-catenary parallel power supply system

In order to eliminate the transient process of the hydrogen energy system of the hydrogen power locomotive upon switching between the grid-connected and standalone control modes, a seamless switching control approach for the hydrogen energy and pantograph-catenary parallel power supply system was proposed in this paper.With the control power target

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Gelled Electrolyte for Nanostructured Lead-acid Battery

In recent years, the storage of energy produced by renewable sources has become a topic of great interest.Lead-acid batteries are widely used in this field, in particular those based on VRLA (Valve-Regulated-Lead Acid) technology, in which the electrolyte is immobilized inside the battery.In this paper, the use of a hydrogel as an electrolyte was c

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A mathematical study of effects of delays arising from the interaction of anti-drug antibody and therapeutic protein in the immune response system

Immunogenicity is the ability of substances to evoke an immune response such as a therapeutic protein drug that is considered as a foreign object in the human body.The rise of the immune response results in the production of Anti-Drug Antibody (ADA) that requires a certain period to be activated Hot Oil Treatments since it is influenced by the numb

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